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Serious reporting deficiencies exist in minimal important difference studies: Current state and suggestions for improvement
Alonso Carrasco-Labra , Tahira Devji, Anila Qasim, Mark Phillips, Bradley C Johnston, Niveditha Devasenapathy, Dena Zeraatkar, Meha Bhatt, Xuejing Jin, Romina Brignardello-Petersen, Olivia Urquhart, Farid Foroutan, Stefan Schandelmaier, Hector Pardo-Hernandez, Robin Wm Vernooij, Hsiaomin Huang, Yamna Rizwan, Reed Siemieniuk, Lyubov Lytvyn, Donald L Patrick, Shanil Ebrahim, Toshi A Furukawa, Gihad Nesrallah, Holger J Schunemann, Mohit Bhandari, Lehana Thabane, Gordon H Guyatt
J Clin Epidemiol . 2022 Jun 24;S0895-4356(22)00161-5. doi: 10.1016/j.jclinepi.2022.06.010. Online ahead of print.
Seeing the patient's perspective: a guide to patient-reported outcome measures and minimal important differences in ophthalmic research.
Qasim A, Devji T, Phillips MR, Wykoff CC, Kaiser PK, Thabane L, Bhandari M, Chaudhary V; Retina Evidence Trials InterNational Alliance (R.E.T.I.N.A.) Study Group.
Eye (Lond). 2022 Feb 23. doi: 10.1038/s41433-022-01989-5.
A systematic survey identified methodological issues in studies estimating anchor-based minimal important differences in patient-reported outcomes.
Wang Y, Devji T, Qasim A, Hao Q, Wong V, Bhatt M, Prasad M, Wang Y, Noori A, Xiao Y, Ghadimi M, Lozano LEC, Phillips MR, Carrasco-Labra A, King M, Terluin B, Terwee C, Walsh M, Furukawa TA, Guyatt GH. 
J Clin Epidemiol. 2021 Nov 6:S0895- 4356(21)00352-8. doi: 10.1016/j.jclinepi.2021.10.028. Online ahead of print.
Minimal important changes in standard deviation units are highly variable and no universally applicable value can be determined.
Tsujimoto T, Fujii T, Tsutsumi Y, Kataoka Y, Tajika A, Okada Y, Carraso-Labra A, Devji T, Wang Y, Guyatt GH, Furukawa TA.
J Clin Epidemiol . 2022 Jan 25;145:92-100. doi: 10.1016/j.jclinepi.2022.01.017. Online ahead of print.
Commentary: Online Platform of Minimal Important Difference estimates for patient reported outcomes: potential and challenges.
Beaton DE, Maxwell LJ. 
 J Clin Epidemiol. 2021 May;133:172-174. doi: 10.1016/j.jclinepi.2021.02.013. Epub 2021 Feb 16.
Minimal important difference estimates for patient-reported outcomes: A systematic survey. 
Carrasco-Labra A, Devji T, Qasim A, Phillips MR, Wang Y, Johnston BC, Devasenapathy N, Zeraatkar D, Bhatt M, Jin X, Brignardello-Petersen R, Urquhart O, Foroutan F, Schandelmaier S, Pardo-Hernandez H, Hao Q, Wong V, Ye Z, Yao L, Vernooij RWM, Huang H, Zeng L, Rizwan Y, Siemieniuk R, Lytvyn L, Patrick DL, Ebrahim S, Furukawa TA, Nesrallah G, Schünemann HJ, Bhandari M, Thabane L, Guyatt GH. 
J Clin Epidemiol. 2021 May;133:61-71. doi: 10.1016/j.jclinepi.2020.11.024. Epub 2020 Dec 13.
Mind the methods of determining minimal important differences: three critical issues to consider. 
Devji T, Carrasco-Labra A, Guyatt G. 
Evid Based Ment Health. 2021 May;24(2):77-81. doi: 10.1136/ebmental-2020-300164. Epub 2020 Aug 24
Evaluating the credibility of anchor based estimates of minimal important differences for patient reported outcomes: instrument development and reliability study.
Devji T, Carrasco-Labra A, Qasim A, Phillips M, Johnston BC, Devasenapathy N, Zeraatkar D, Bhatt M, Jin X, Brignardello-Petersen R, Urquhart O. 
BMJ. 2020 Jun 4;369:m1714. doi: 10.1136/bmj.m1714
Patient‐reported outcomes. Cochrane Handbook for Systematic Reviews of Interventions.
Johnston BC, Patrick DL, Devji T, Maxwell LJ, Bingham III CO, Beaton DE, Boers M, Briel M, Busse JW, Carrasco‐Labra A, Christensen R. 
2019 Sep 23:479-92.
Minimal important differences for improvement in shoulder condition patient-reported outcomes: a systematic review to inform a BMJ Rapid Recommendation. 
Hao Q, Devji T, Zeraatkar D, Wang Y, Qasim A, Siemieniuk RAC, Vandvik PO, Lähdeoja T, Carrasco-Labra A, Agoritsas T, Guyatt G. 
BMJ Open. 2019 Feb 20;9(2):e028777. doi: 10.1136/bmjopen-2018-028777
Presentation approaches for enhancing interpretability of patient-reported outcomes (PROs) in meta-analysis: A protocol for a systematic survey of Cochrane reviews. 
Devji T, Johnston BCJ, Patrick DL, Bhandari M, Thabane L, Guyatt GH. 
BMJ Open, 7(9), e017138. doi:10.1136/bmjopen-2017-017138
Application of minimal important differences in degenerative knee disease outcomes: a systematic review and case study to inform BMJ Rapid Recommendations. 
Devji T, Guyatt GH, Lytvyn L, Brignardello-Petersen R, Foroutan F, Sadeghirad B, Buchbinder R, Poolman RW, Harris IA, Carrasco-Labra A, Siemieniuk RAC, Vandvik PO. 
BMJ Open. 2017 May 11;7(5):e015587. doi: 10.1136/bmjopen-2016-015587.
Minimally important difference estimates and methods: a protocol. 
Johnston BC, Ebrahim S, Carrasco-Labra A, Furukawa TA, Patrick DL, Crawford MW, Hemmelgarn BR, Schunemann HJ, Guyatt GH, Nesrallah G. 
BMJ Open. 2015 Oct 1;5(10):e007953. doi: 10.1136/bmjopen-2015-007953

Issues in using, interpreting, and presenting patient-reported outcomes in Cochrane Reviews.
Devji T, Patrick D, Guyatt G.
Abstracts of the Cochrane Colloquium, Edinburgh, United Kingdom. September 2018.
Meta-analysis of patient-reported outcomes and application of minimal important differences to facilitate interpretation in systematic reviews and guideline development.
Devji T, Carrasco-Labra A, Guyatt G, Qasim A, Phillips M, Patrick D, Johnston B, Ebrahim S, Nesrallah G, Schünemann H, Furukawa T.
Abstracts of the Cochrane Colloquium, Edinburgh, United Kingdom. September 2018.
Meta-analysis of patient-reported outcomes and application of minimal important differences to facilitate interpretation in systematic reviews and guideline development. Abstracts of the Global Evidence Summit, Cape Town, South Africa.
Devji T, Carrasco-Labra A, Guyatt G, Patrick D, Johnston B, Nesrallah G. 
Cochrane Database of Systematic Reviews 2017, Issue 9 (Suppl 2).doi.org/10.1002/14651858.CD201702.

Designing a Study to Determine the Minimal Important Difference (MID) for the ALSFRS-R.
Shefner J, Al-Chalabi A, Andrews J, Chio A, Cudkowicz M, Doane D, Genge A, Guyatt G, Hardiman O, Kum E, Simmons Z, van Damme P, van den Berg L, Kupfer S, Meng L, Simkins T, Wei J, Wolff A, Rudnicki S.
2022 Annual NEALS Meeting, Florida, United States. November 2022.
Symposium 8: Moving the interpretation of PRO scores
forward: MIDs et al! Critical insights from a large systematic review of anchor-based minimal important difference (MID) estimates for patient-reported outcome measures (PROMs).
Devji T (presenter).
ISOQOL, San Diego, United States. October 2019.
Interpretation of patient-reported outcome measures: an inventory of over 3000 minimally important difference estimates and an assessment of their credibility.
Carrasco-Labra A (presenter), Devji T, Qasim A, Phillips M, Devasenapathy N, Zeraatkar D, Bhatt M, Jin X, Brignardello-Petersen R, Urqhart O, Faroutan F, Schandelmaier S, Pardo-Hernandez H, Vernooij RW, Huang W, Rizwan Y, Lytvyn L, Siemieniuk R, Johnston BC, Ebrahim S, Furukawa TA, Patrick DL, Schünemann HJ, Nesrallah G, Guyatt G.
Abstracts of the Cochrane Colloquium, Edinburgh, United Kingdom. Sept 2018
Interpretation of patient-reported outcome measures: an inventory of over 3000 minimally important difference estimates and an assessment of their credibility
Carrasco-Labra A (presenter), Devji T, Qasim A, Phillips M, Devasenapathy N, Zeraatkar D, Bhatt M, Jin X, Brignardello-Petersen R, Urqhart O, Faroutan F, Schandelmaier S, Pardo-Hernandez H, Vernooij RW, Huang W, Rizwan Y, Lytvyn L, Siemieniuk R, Johnston BC, Ebrahim S, Furukawa TA, Patrick DL, Schünemann HJ, Nesrallah G, Guyatt G.
Guidelines International Network, Manchester, United Kingdom. Sept 2018
A new tool to measure credibility of studies determining minimally important difference estimates.
Devji T (presenter), Carrasco-Labra A, Lytvyn L, Johnston B, Ebrahim S, Furukawa T, Patrick D, Schünemann H, Nesrallah G, Guyatt G. 
Abstracts of the Global Evidence Summit, Cape Town, South Africa. Cochrane Database of Systematic Reviews 2017, Issue 9 (Suppl 2).doi.org/10.1002/14651858.CD201702.
Minimally important difference estimates and assessment of their credibility for patient-reported outcomes in adults: A systematic survey.
Carrasco-Labra A, Devji T (presenter), Lytvyn L, Brignardello-Petersen R, Prasad M, Devasenapathy N, Zeraatkar D, Foroutan F, Pardo-Hernandez H, Vernooij RW, Jin X, Ross S, Quach K, Schandelmaier S, Panepinto O, Bhatt M, Qasim A, Phillips M, Furukawa TA, Patrick DL, Schünemann HJ, Johnston BC, Ebrahim S, Nesrallah G, Guyatt G. 
Abstracts of the Global Evidence Summit, Cape Town, South Africa. Cochrane Database of Systematic Reviews 2017, Issue 9 (Suppl 2).doi.org/10.1002/14651858.CD201702.
MetaPROM – Enhancing the interpretation of Meta-analyses of Patient-
Reported Outcome Measures through a Microsoft Excel-based statistical
software program
Devji T (presenter), Guyatt G, Svendrovski A, da Costa B, Johnston BC. 
Cochrane Database of Systematic Reviews 2017, Issue 9 (Suppl 2).doi.org/10.1002/14651858.CD201702.
The importance of minimal important differences to inform systematic
reviews and clinical practice guidelines: an example.
Devji T (presenter), Guyatt G, Lytvyn L, Brignardello-Petersen R, Foroutan F, Sadeghirad B, Buchbinder R, Harris I, Carrasco-Labra A, Siemieniuk R, Vandvik P. 
Abstracts of the Global Evidence Summit, Cape Town, South Africa. Cochrane Database of Systematic Reviews 2017, Issue 9 (Suppl 2).doi.org/10.1002/14651858.CD201702.
Enhancing the Interpretability of patient-reported outcomes in
systematic reviews and guidelines
Devji T (presenter)
GRADE Working Group Meeting. Rome, Italy, April 2017
Reporting and Application of minimally important differences in randomized controlled trials evaluating patient reported outcomes: a systematic survey.
Devji T (presenter), Carrasco-Labra A, Bhatt M, Evaniew N, Florez ID, Montoya L, Perera S, Quach K, Riva JJ, Siemieniuk RA, Sivanand A, Vercammen K, ZeeratkarD, Johnston B, Cook DJ, Guyatt G, Ebrahim S.
Cochrane Colloquium, Seoul, South Korea, October 2016
Minimally important difference estimates and assessment of its credibility for patient reported outcomes in adults: A Systematic survey.
Carrasco-Labra A (presenter), Johnston BC, Ebrahim S et al.
Cochrane Colloquium, Vienna, Austria, October 2015
A new tool to measure credibility of studies determining minimally important difference estimates.
Carrasco-Labra A (presenter), Johnston BC, Ebrahim S et al.
Cochrane Colloquium, Vienna, Austria, October 2015